Triazole as Pharmaceuticals Potentials
نویسندگان
چکیده
In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics are found in abundance in most of the medicinal compounds. The triazoles are said to be the isosters of imidazoles in which the carbon atom of imidazole is isosterically replaced by nitrogen. Triazole & its derivatives have a wide range of application. They are predominantly among the type of compounds used such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antihypertensive, antimalarial, antianxiety, antidepressant, and antihistaminic, antitubercular agents etc. The derivatization of Triazole ring is based on the phenomenon of bioisosterism in which replacement of oxygen of oxadiazole nucleus with nitrogen triazole analogue.
منابع مشابه
New 1,2,3-triazole ligands through click reactions and their palladium and platinum complexes.
The new ligands, 1-(4-isopropyl phenyl)-4-(2-pyridyl)-1,2,3-triazole, 1 and 1-(mesityl)-4-(2-pyridyl)-1,2,3-triazole, 2 were prepared by the reactions of the respective azides with 2-ethynylpyridine following the "click method". These ligands together with the reported ligands 1-(phenyl)-4-(2-pyridyl)-1,2,3-triazole, 3 and 1-(benzyl)-4-(2-pyridyl)-1,2,3-triazole, 4 were reacted with palladium a...
متن کاملPreparation and evaluation of glycosylated arginine-glycine-aspartate (RGD) derivatives for integrin targeting.
Arginine-glycine-aspartate (RGD) derivatives were prepared by a combination of solid-phase and solution-phase synthesis for selective targeting of alpha vbeta 3 integrin expressed in tumors. In order to evaluate the value of a triazole moiety as a proposed amide isostere, the side chain glycosylated cyclic RGD ( cRGD) peptides were synthesized with either a natural amide linkage or a triazole. ...
متن کاملCytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line
BACKGROUND Simple glycoside surfactants represent a class of chemicals that are produced from renewable raw materials. They are considered to be environmentally safe and, therefore, are increasingly used as pharmaceuticals, detergents, and personal care products. Although they display low to moderate toxicity in cells in culture, the underlying mechanisms of surfactant-mediated cytotoxicity are...
متن کاملOrganic & Biomolecular Chemistry Tetrathiafulvalene Mono-and Bis-1,2,3-triazole Precursors by Click Chemistry: Structural Diversity and Reactivity †
PAPER Thomas Biet and Narcis Avarvari Tetrathiafulvalene mono-and bis-1,2,3-triazole precursors by click chemistry: structural diversity and reactivity The donor ortho-dimethyl-TTF-(N-n-Bu-1,2,3-triazole) 1,5-isomer has been synthesized by click chemistry following a ruthenium-catalyzed azide–alkyne cycloaddition procedure. The single crystal X-ray analysis showed a planar conformation between ...
متن کاملConformational properties of 1,4- and 1,5-substituted 1,2,3-triazole amino acids – building units for peptidic foldamers.
Peptidic foldamers have recently emerged as a novel class of artificial oligomers with properties and structural diversity similar to that of natural peptides, but possessing additional interesting features granting them great potential for applications in fields from nanotechnology to pharmaceuticals. Among these, foldamers containing 1,4- and 1,5-substitued triazole amino acids are easily pre...
متن کامل